NEWS

Publication of seven articles in PLOS Neglected Tropical Diseases

Over the past six years, NIDIAG has tried to bridge the gap between innovation and practice in the diagnosis of neglected tropical diseases. The scientists have now published a set a seven articles in PLOS Neglected Tropical Diseases, which describe the specific challenges, propose solutions and provide working documents for implementing quality assured clinical research into neglected tropical diseases.

Read the press release here.

Final Consortium meeting, Yogyakarta, Indonesia

The final Consortium meeting will held in Yogyakarta, Indonesia, on 14-16 March 2016. This meeting will gather together all NIDIAG Partners and will be the opportunity to present and discuss the latest progresses made in NIDIAG, to review the project as a whole and to discuss the possibilities for the future.

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Press

RTNC2 Développement: RDC TV local chain

 

Allo Docteur Programme on RDC TV local Channel

NIDIAG Allo Docteur

Presentation of the NIDIAG activities with investigators from NIDIAG project. Please consult these 2 links: link1 and link 2.

 

Publications in peer-reviewed journals with acknowledgement of NIDIAG

 

 

2015

Becker SL, Piraisoody N, Kramme S, Marti H, Silué KD, Panning M, Nickel B, Kern WV, Herrmann M, Hatz CF, N’Goran EK, Utzinger J, von Müller L. Real-time PCR for detection of Strongyloides stercoralis in human stool samples from Côte d’Ivoire: diagnostic accuracy, inter-laboratory comparison and patterns of hookworm co-infection. Acta Trop 2015 Jul 26; 150:210-217 [Epub ahead of print].

Becker SL, Chatigre JK, Coulibaly JT, Mertens P, Bonfoh B, Herrmann M, Kuijper EJ, N'Goran EK, Utzinger J, von Müller L. Molecular and culture-based diagnosis of Clostridium difficile isolates from Côte d'Ivoire after prolonged storage at disrupted cold chain conditions. Trans R Soc Trop Med Hyg. 2015 Oct;109(10):660-8. doi: 10.1093/trstmh/trv071. Epub 2015 Sep 8.

Becker SL, Chappuis F, Polman K, N'Goran EK, von Müller L, Utzinger J. Reply: epidemiological studies need asymptomatic controls. Clin Microbiol Infect 2015 (electronically published ahead of print), http://dx.doi.org/10.1016/j.cmi.2015.04.024

Becker SL, Chatigre JK, Gohou JP, Coulibaly JT, Leuppi R, Polman K et al. Combined stool-based multiplex PCR and microscopy for enhanced pathogen detection in patients with persistent diarrhoea and asymptomatic controls from Côte d'Ivoire. Clin Microbiol Infect 2015 (electronically published ahead of print), http://dx.doi.org/10.1016/j.cmi.2015.02.016

Utzinger J, Becker SL, van Lieshout L, van Dam GJ, Knopp S. New diagnostic tools in schistosomiasis. Clin Microbiol Infect 2015 (electronically published ahead of print), http://dx.doi.org/10.1016/j.cmi.2015.03.014

 

 

2014

 

Rogé S, Van Nieuwenhove L, Meul M, Heykers A, Brouwer de Koning A, Bebronne N, Guisez Y, Büscher P. Recombinant antigens expressed in Pichia pastoris for the diagnosis of sleeping sickness caused by Trypanosoma brucei gambiense. PLoS Negl Trop Dis 2014; 2014; 8: e3006.

Bhattacharyya T, Ayandeh A, Falconar AK, Sundar S, El-Safi S, Gripenberg MA, Bowes DE, Thunissen C, Singh OP, Kumar R, Ahmed O, Eisa O, Saad A, Silva Pereira S, Boelaert M, Mertens P, Miles MA. IgG1 as a Potential Biomarker of Post-chemotherapeutic Relapse in Visceral Leishmaniasis, and Adaptation to a Rapid Diagnostic Test. PLoS Negl Trop Dis 2014; 8(10): e3273.

Bhattacharyya T, Bowes DE, El-Safi S, Sundar S, Falconar AK, Singh OP, Kumar R, Ahmed O, Boelaert M, Miles MA. Significantly lower anti-Leishmania IgG responses in Sudanese versus Indian visceral leishmaniasis. PLoS Negl Trop Dis 2014; 8(2): e2675.

Bottieau E, Mukendi D, Kalo JR, Mpanya A, Lutumba P, Barbé B, Chappuis F, Lunguya O, Boelaert M, Jacobs J. Fatal Chromobacterium violaceum bacteraemia in rural Bandundu, Democratic Republic of the Congo. New Microbes New Infect 2014 Nov 12;3:21-3.

Büscher P, Mertens P, Leclipteux T, Gilleman Q, Jacquet D, Mumba-Ngoyi D, Pyana PP, Boelaert M, Lejon V. Sensitivity and specificity of HAT Sero-K-SeT, a rapid diagnostic test for serodiagnosis of sleeping sickness caused by Trypanosoma brucei gambiense: a case-control study. Lancet Glob Health 2014; 2(6): e359-63.

Mpanya A, Boelaert M, Baloji S, Matangila J, Lubanza S, Bottieau E, Chappuis F, Lutumba P, Hendrickx D. Diagnostic work-up of neurological syndromes in a rural African setting: knowledge, attitudes and practices of health care providers. PLoS One 2014; 9(10): e110167.

 

2013

 

Becker SL, Vogt J, Knopp S, Panning M, Warhurst DC, Polman K, Marti H, von Müller L, Yansouni CP, Jacobs J, Bottieau E, Sacko M, Rijal S, Meyanti F, Miles MA, Boelaert M, Lutumba P, van Lieshout L, N'Goran EK, Chappuis F, Utzinger J. Persistent digestive disorders in the tropics: causative infectious pathogens and reference diagnostic tests. BMC Infect Dis 2013; 13: 37.

Bhattacharyya T, Boelaert M, Miles MA. Comparison of visceral leishmaniasis diagnostic antigens in African and Asian Leishmania donovani reveals extensive diversity and region-specific polymorphisms. PLoS Negl Trop Dis 2013; 7(2): e2057.

Büscher P, Mumba Ngoyi D, Pyana PP, Mertens P, Leclipteux T, Gilleman Q, Camara O, Camara M, Leno M, Sakande H, Dama D, Bucheton B, Jamonneau V, Lejon V. New rapid tests for antibody detection serodiagnosis in Trypanosoma brucei gambiense sleeping sickness. HAT Platform Newsletter 2013; 13: 21-22.

Büscher P, Gilleman Q, Lejon V. Rapid diagnostic tests for sleeping sickness. N Engl J Med 2013; 368(11): 1069.

Chappuis F, Alirol E, d'Acremont V, Bottieau E, Yansouni CP. Rapid diagnostic tests for non-malarial febrile illness in the tropics. Clin Microbiol Infect 2013; 19(5): 422-31.

Fürst T, Silué KD, Ouattara M, Adiossan LG, N'Goran DN, Yao AJ, Koné S, N'Goran EK, Utzinger J, Bogoch II. Patients routinely report more symptoms to experienced field enumerators than physicians in rural Cote d'Ivoire. Am J Trop Med Hyg 2013; 89(3): 592-6.

Knopp S, Becker SL, Ingram KJ, Keiser J, Utzinger J. Diagnosis and treatment of schistosomiasis in children in the era of intensified control. Expert Rev Anti Infect Ther 2013 Nov; 11(11):1237-58.

Meheus F, Abuzaid AA, Baltussen R, Younis BM, Balasegaram M, Khalil EA, Boelaert M, Musa AM. The economic burden of visceral leishmaniasis in Sudan: an assessment of provider and household costs. Am J Trop Med Hyg 2013; 89(6): 1146-53.

Yansouni CP, Bottieau E, Lutumba P, Winkler AS, Lynen L, Büscher P, Jacobs J, Gillet P, Lejon V, Alirol E, Polman K, Utzinger J, Miles MA, Peeling RW, Muyembe JJ, Chappuis F, Boelaert M. Rapid diagnostic tests for neurological infections in central Africa. Lancet Infect Dis 2013; 13(6): 546-58.

 

 

2012

 

Yansouni CP, Bottieau E, Chappuis F, Phoba MF, Lunguya O, Ifeka BB, Jacobs J. Rapid diagnostic tests for a coordinated approach to fever syndromes in low-resource settings. Clin Infect Dis 2012; 55(4): 610-1 (letter); 611-2 (author reply).

 

 

Related publications in peer-reviewed journals without acknowledgement of NIDIAG

 

2013

 

Bottieau E. Point-of-care testing: filling the diagnostic gaps in tropical medicine? Clin Microbiol Infect 2013; 19(5): 397-8.

Uranw S, Meheus F, Baltussen R, Rijal S, Boelaert M. The household costs of visceral leishmaniasis care in south-eastern Nepal. PLoS Negl Trop Dis 2013; 7(2): e2062.

 

Presentations at international meetings with acknowledgement of NIDIAG: oral sessions

 

2015

 

Verdonck K. Clinical spectrum, main etiologies and outcome of neurological disorders in the rural Hospital of Mosango, Province of Bandundu, Democratic Republic of the Congo. Oral session presented at: 9th European Congress on Tropical Medicine and International Health; 2015 Sep 6-10; Basel, Switzerland.

Meheus F. Diagnostic guidance for patients presenting with persistent fever in neglected tropical disease endemic areas of Cambodia, the Democratic Republic of Congo, Nepal and Sudan. Oral session presented at: 9th European Congress on Tropical Medicine and International Health; 2015 Sep 6-10; Basel, Switzerland.

Becker S. Stool-based polymerase chain reaction for the diagnosis of multiple pathogens in Mali: a case-control study. Oral session presented at: 9th European Congress on Tropical Medicine and International Health; 2015 Sep 6-10; Basel, Switzerland.

Chappuis F. Diagnostic guidance for patients presenting with persistent fever in neglected tropical disease endemic areas of Cambodia, the Democratic Republic of Congo, Nepal and Sudan. Oral session presented at: 9th European Congress on Tropical Medicine and International Health; 2015 Sep 6-10; Basel, Switzerland.

Bottieau E. Clinical spectrum, main etiologies and outcome of neurological disorders in the rural Hospital of Mosango, Province of Bandundu, Democratic Republic of the Congo. Oral session presented at: 9th European Congress on Tropical Medicine and International Health; 2015 Sep 6-10; Basel, Switzerland.

Q. Gilleman. Development of a rapid diagnostic test for active case detection in sleeping sickness control: recHAT Sero-Strip. Oral session presented at: 9th European Congress on Tropical Medicine and International Health; 2015 Sep 6-10; Basel, Switzerland.
2014

Chappuis F. From a disease-specific to a syndromic diagnostic approach: the cases of visceral leishmaniasis and human African trypanosomiasis. Oral session presented at: ASTMH, 63rd Annual Meeting; 2014 Nov 2-6; New Orleans, USA.

El Safi S. The Role of Rapid Diagnostic Tests (RDTs) in Improving the Clinical Management of Patients Presenting with Chronic Fever. Oral session presented at: ASLM, 2nd international conference; 2014 Nov 30 – Dec 4; Cape Town, South Africa.

Jacobs J. Quality Issues in RDTs for Neglected Infectious Diseases. Oral session presented at: ASLM, 2nd international conference; 2014 Nov 30 – Dec 4; Cape Town, South Africa.

Lutumba P, Sacko M. The Role of RDTs in Improving the Clinical Management of Patients Presenting with Neurological Syndrome. Oral session presented at: ASLM, 2nd international conference; 2014 Nov 30 – Dec 4; Cape Town, South Africa.

Roge S. Diagnosis of human African trypanosomiasis with antigens expressed in Pichia pastoris. Oral presentation at: Pichia expression conference; 2014 Mar 2-5 March 2-5; San Diego, California, USA.

 

2013

 

Bhattacharyya T. Understanding differential regional sensitivity of rapid diagnosis for visceral leishmaniasis. Oral session presented at: WorldLeish5; 2013 May 13-17; Porto de Galinhas, Brazil.

Büscher P, Mertens P, Leclipteux T, Gilleman Q, Jacquet D, Mumba Ngoyi D, Pyana PP, Menten J, Lejon V. Diagnostic accuracy under field conditions of HAT Sero K-Set, a rapid diagnostic test for sleeping sickness. Oral session presented at: BSP Autumn Symposium, Advances in diagnostics for infectious diseases; 2013 Sep 25-26; Liverpool, UK.

Büscher P, Mertens P, Leclipteux T, Gilleman Q, Jacquet D, Mumba-Ngoyi D, Pyana PP, Menten J, Lejon V. Diagnostic accuracy under field conditions of HAT Sero K-SeT, a rapid diagnostic test for sleeping sickness. Oral session presented at: 32nd ISCTRC meeting; 2013 Sep 8-12; Khartoum, Sudan.

Büscher P, Mertens P, Leclipteux T, Gilleman Q, Jacquet D, Mumba Ngoyi D, Pyana PP, Menten J, Lejon V. Diagnostic accuracy under field conditions of HAT Sero K-SeT, a rapid diagnostic test for sleeping sickness. Oral session presented at: DNDi Africa. A decade of R&D for neglected diseases in Africa. Endemic country research and development for patient access; 2013 Jun 3-7; Nairobi, Kenya.

Mumba Ngoyi D, Gilleman Q, Pyana P, Lejon V, Menten J, Büscher P. Les nouveaux tests de diagnostic rapide pour la THA à T.b.gambiense. Oral session presented at: CIPIP - 6th International Congress on Infectious and Parasitic Diseases; 2013 Jun 13-15; Kinshasa, DRC. Ann Afr Med 2013; 6(1,4).

Mukendi D, Kalo JR, Bottieau E, Barbe B, Gillet P, Mpanya A, Yansouni CP, Winkler A, Muyembe JJ, Jacobs J, Chappuis F, Boelart M, Lutumba P. Résultats préliminaires de l’étude neurologique NIDIAG explorant les causes d’affections neurologiques à l’Hôpital Général de Référence de Mosango, Province de Bandundu, République Démocratique du Congo. Oral session presented at: CIPIP - 6th International Congress on Infectious and Parasitic Diseases; 2013 Jun 13-15; Kinshasa, DRC. Ann Afr Med 2013 6(2).

 

2012

 

Büscher P. Tools for elimination: screening and diagnostic tools. Oral session presented at: WHO meeting on human African trypanosomiasis (T.b. gambiense) elimination; 2012 Dec 3-5; Geneva, Switzerland.

Büscher P. Sleeping sickness epidemiology and control: current status and perspectives for the near future. Oral session presented at: XVIII International Congress for Tropical Medicine and Malaria and XLVIII Congress of the Brazilian Society of Tropical Medicine; 2012 Sep 23-27; Rio de Janeiro, Brazil.

 

Presentations at international meetings with acknowledgement of NIDIAG: poster sessions

 

2015

 

Becker S, Yap P. Parasitological characterisation of persistent digestive disorders in Mali: a case-control study. Poster session presented at: 9th European Congress on Tropical Medicine and International Health; 2015 Sep 6-10; Basel, Switzerland.

Meheus F, Burza S. The cost and cost-effectiveness of IgG1 as point-of-care rapid diagnostic tests to detect relapse of visceral leishmaniasis. Poster session presented at: 9th European Congress on Tropical Medicine and International Health; 2015 Sep 6-10; Basel, Switzerland.

 

2014

 

Becker J et al. Luminex® xTAG GPP multiplex PCR assay for the diagnosis of gastrointestinal pathogens: preliminary findings from a case-control study in Côte d'Ivoire. Poster session presented at: 65th Annual Meeting of the German Society for Hygiene and Microbiology (DGHM); 2014 Sep 22-25; Rostock, Germany.

Piraisoody N, Kramme S, Marti H, Silué KD, Panning M, Herrmann M, Hatz CF, N’Goran EK, Utzinger J, von Müller L, Becker SL. Diagnostic accuracy and inter-laboratory comparison of microscopy and real-time PCR for detection of Strongyloides stercoralis. Poster session presented at: 66th Annual Meeting of the German Society of Hygiene and Microbiology; 2014 Oct 5-8; Dresden, Germany.

Traore M. Syndromic approach to neglected infectious diseases (NID) at primary health care level: an international collaboration on integrated diagnosis-treatment platforms. Poster session presented at: ASTMH, 63rd Annual Meeting; 2014 Nov 2-6; New Orleans, USA.

 

2013

 

Bottieau E, Mukendi D, Kalo JR, Barbe B, Gillet P, Mpanya A, Yansouni CP, Winkler A, Lutumba P, Jacobs J, Chappuis F, Boelart M, Lutumba P. Etiology and outcome of neurological disorders in the Rural Hospital of Mosango, Province of Bandundu, Democratic Republic of Congo: preliminary results. Poster session presented at: 8th European Congress on Tropical Medicine and International Health & 5th Conference of the Scandinavian-Baltic Society for Parasitology; 2013 Sep 10–13; Copenhagen, Denmark.

Camara O, Camara M, Sakande H, Leno M, Dama E, Gilleman Q, Büscher P, Bucheton B, Jamonneau V, Lejon V. Preliminary evaluation of the diagnostic performance of the HAT Sero-K-Set rapid diagnostic test in Guinea. Poster session presented at: 32nd ISCTRC meeting; 2013 Sep 8-12; Khartoum, Sudan.

Rogé S, Meul M, Guisez Y, Gilleman Q, Simon T, Büscher P. Development of rapid diagnostic tests for surra and sleeping sickness based on recombinant variant surface glycoproteins. Poster session presented at: BSP Autumn Symposium, Advances in diagnostics for infectious diseases; 2013 Sep 25-26; Liverpool, UK.

 

2012

 

Gilleman Q, Mertens P, Büscher P. Development of a Rapid Diagnostic Test for detection of sleeping sickness. Poster session presented at: Science For Business, BioWin Day 2012, Innovation of the economy and innovation of the patients; 2012 Nov 28; Louvain-la-Neuve, Belgium.

Rogé S, Meul M, Guisez Y, Gilleman Q, Simon T, Büscher P. Development of rapid diagnostic tests for surra and sleeping sickness based on recombinant antigens expressed in Pichia pastoris. Poster session presented at: Pathogens’ survival strategies, from fundamentals to field. ITM 54th International Colloquium; 2012 Dec3-5; Antwerp, Belgium.

 

Other media releases with acknowledgement of NIDIAG

 

2015

 

NIDIAG A guide to spotting forgotten diseases. Investing in European success - EU-Africa cooperation in science, technology and innovation. Internet publication; 2015 August 3. https://ec.europa.eu/programmes/horizon2020/en/news/investing-european-success-eu-africa-cooperation-science-technology-and-innovation-0

NIDIAG Une assistance pour diagnostiquer les maladies «oubliées». Investir dans la réussite européenne - Coopération entre l’Union européenne et l’Afrique dans le domaine des sciences, des technologies et de l’innovation. Internet publication; 2015 August 3. https://ec.europa.eu/programmes/horizon2020/en/news/investing-european-success-eu-africa-cooperation-science-technology-and-innovation-0

NIDIAG Um guia para detetar doenças esquecidas. Investir no sucesso europeu - Cooperação UE-África nos domínios da ciência, tecnologia e inovação. Internet publication; 2015 August 3.
https://ec.europa.eu/programmes/horizon2020/en/news/investing-european-success-eu-africa-cooperation-science-technology-and-innovation-0  

EU fighting neglected infectious diseases and training local health professionals in least developed countries. Internet publication; 2015 January 28. https://europa.eu/eyd2015/en/european-union/stories/nidiag

 

2014

 

Boelaert M, Lutumba P, Chappuis F, Sacko M. Allo Docteur, RTNC2 Développement (Radio et Télévision Nationale du Congo). Interview on NID; 2014 Apr; Kinshasa, DRC. https://www.youtube.com/watch?v=Q3N2hMUCL6c https://www.youtube.com/watch?v=fYB1yHJv584

Büscher P. Allo Docteur, RTNC2 Développement (Radio et Télévision Nationale du Congo). Interview on the HAT Sero-K-SeT; 2014 Sep 19; Kinshasa, DRC.

Büscher P. Nouveau test rapide pour le diagnostic de la maladie du sommeil. Press release; 2014 Sep 17; Kinshasa, DRC.

Büscher P. Feu vert pour un test rapide pour la maladie du sommeil. Internet publication; 2014 May 9; http://www.itg.be/itg/GeneralSite/Default.aspx?WPID=688&MIID=637&IID=349&L=F.